Founded in 2003, Shanghai ChemPartner Co., Ltd.("ChemPartner") is a R&D contract research company to provide customized services to international pharmaceutical, biotech, agrochemical, and chemical companies.
ChemPartner currently has a team of more than 250 scientists, including more than 40 PhDs, who either had extensive ovesea R&D experiences in pharmaceutical / biotech companies, universities, or were trained at top chemistry research institutes in China before joining ChemPartner.
ChemPartner has a complete list of contract services in synthetic organic chemistry and its related areas. Our clients come from global pharmaceutical, biotech, agrochemical, and specialty chemical companies as well as academic organizations. Dedicated to contract research services, ChemPartner offers its customers with compelling values to their R&D programs based on a comparable product quality and timeline management to that offered by similar service suppliers in the Unite States and Europe while providing a significantly operating cost reduction.
ChemPartner provides its clients with high quality services in a timely manner in the form of FTE (full time equivalent) or one-off synthesis (based upon agreed price) arrangement. We currently carry the following types of discovery chemistry services.
Custom Synthesis (>95% purity, mg, gram to kg scale)
- Building blocks
- Key and advanced intermediates
- Target synthesis
High-throughput synthesis and purification
- Focused library generation
- High-throughput purification
- Combinatorial library synthesis
At ChemPartner, project teams will be organized with Ph.D., MS, and BS level chemists who have significant working experience to meet the particular project needs in technology and communication.
All the documents generated during the course of a project will be written in English and properly archived. ?They include lab notebooks, project update reports, email messages, project final reports, presentations, etc.
Project teams will issue weekly updates and target synthesis reports all written in English. A target synthesis report, which includes all aspects of the project chemistry from synthetic routes, detailed experimental procedures, spectroscopic data, and references, will be submitted to clients together with the corresponding target products.
All of our products will be fully characterized using our in-house NMR and LC-MS to justify their integrity before submitting to clients. ?A target product can only be released for shipping with the approval from both of the project head and the principal analytical chemist.
Our shipping and handling specialists will generate the needed paperwork and pack the product in a proper way to meet the requirements for international air transportation. ?Products are usually shipped to our clients through international express parcel delivery services.
ChemPartner is capable to design, create and deliver a wide range of small molecule libraries on a contract basis. Using parallel synthesis techniques, we can rapidly generate focused libraries based on given target molecules or scaffolds of interest. ?Every compound synthesized at ChemPartner will be purified to 85% or greater as verified by ELSD and UV. ?Around 5% to 10% of compounds of each library will be also characterized by proton NMR for chemical integrity. We currently offer the services as shown in the following list.
- Library design
- Focused library synthesis
- Combinatorial library synthesis
The analytical department is fully equipped with a wide range of state-of-the-art instruments such as Agilent and Shimadzu LC-MS, Thermo Electron GC-MS, Shimadzu HPLC and GC, Shimadzu and Gilson preparative HPLC, and Varian 300MHz NMR. Our service laboratories are consisted of analytical scientists across many disciplines. The main goal of the department is to provide our synthetic chemists with professional services from compound purification to structure characterization. We also serve our clients in process method development and validation.
ChemPartner isdedicated to providing the global pharmaceutical industry with high quality, fast, and cost-effective services in small molecule drug discovery. A whole spectrum of modern medicinal chemistry tools, such as combinatorial chemistry, CAMD, as well as other laboratory methods (microwave-assisted reaction, Combi-Flash chromatographic purification systems, etc.), has been implemented in our labs to expedite SAR studies. We currently provide the following major medicinal chemistry services.
- Hit exploration and evaluation
- Lead optimization
The Process Group at ChemPartner provides contract R&D and manufacturing services to clients by developing cost efficient and environmentally benign processes for bulk chemical production. The process research laboratories are fully equipped to meet our needs in process route scouting, reaction optimization and Kg-scale sample preparation. We offer the following process R&D services.
- Synthetic process route scouting
- Experimental design
- Thermal hazard screening of chemical reactions & compounds
- Analytical support: method development, compound identification, characterization, specification
Pilot plant facility:
The pilot plant has been designed to comply with the cGMP regulations (batch size ranging from <1 Kg up to 200 Kg).
- 10 Reactors sizing from 100L to 1000L (glass-lined & stainless steel).
- Temperature control ranging from -80 oC up to 200 oC.
- Vacuum capability reaching as low as 0.1 Torr.
Absorption, Distribution, Metabolism and Excretion (ADME) Studies
Our scientists and skilled laboratory staff operate a series of bioanalytical equipment and a SPF (Special Pathogeny Free) rodent animal facility for high-quality pharmacokinetic evaluation on customer’s compounds. Experimental designs can be customized to meet the particular needs in different projects and various dosing routes, as designated by clients.
Routine ADME studies performed are listed as the follows.
- In vivo absolute oral bioavailability evaluations
- Site-specific absorption of intestine studies using intestine infusion techniques
- Effect of gender, food and drug interaction on pharmacokinetics judged by blood or plasma pharmacokinetic result analysis
- Plasma protein binding investigation usually using equilibrium dialysis method
- Metabolite identification and metabolic profiling by mass spectrometry
- Tissue distribution of parent drug and its metabolites
- Excretion mass balance by analyzing urine, feces, bile and occasionally expired air samples for parent drug and individual metabolites using LC/MS/MS
- In vitro metabolic stability (microsomes, S9 and cytosol)
- In vivo P450 induction and inhibition studies
Natural Product Chemistry
The Phytochemistry Group at ChemPartner offers traditional Chinese medicine (TCM) R&D. With an expertise in TCM theory, clinical practice and database management, we are able to help our customers in chemical ingredient study and bioactivity screening toward development of new drug candidates for clinical trials. We offer the following phytochemistry R&D services.
- Herbal medicine standardization
- Traditional recipe modernization
- Bioactive compound R&D
Computational Chemistry And Drug Design
The Laboratory of Computer Aided Drug Design conducts structure-based design of small molecule inhibitors, novel lead identification by high throughput in silico screening of small molecular databases targeted on different diseases using various methodologies, lead optimization and binding conformation predicted by analysis of active site and grid probe energy, homologous modeling and pharmacophore prediction for structurally-unknown drug targets, dynamic simulation of molecular interaction between macrobiomolecules and small molecule ligands; QSAR analysis and prediction model development etc. We also provide services on combinatorial library design using specific software to guarantee synthetic feasibility and building block diversity.